4-Fluoro-3-carboxyphenylboronic acid
5-(dihydroxyboranyl)-2-fluorobenzoic acid
CAS: 120153-08-4
Molecular Formula: C7H6BFO4
4-Fluoro-3-carboxyphenylboronic acid - Names and Identifiers
| Name | 5-(dihydroxyboranyl)-2-fluorobenzoic acid |
| Synonyms | 4-Borono-2-fluorobenzoic acid 5-Borono-2-fluorobenzoic acid 4-Carboxy-3-Fluorophenylboroni 4-Carboxy-3-fluorophenylboronic acid 4-Fluoro-3-carboxyphenylboronic acid 4-CARBOXY-3-FLUOROPHENYLBORONIC ACID 4-Carboxy-3-fluorobenzeneboronic acid 4-CARBOXY-3-FLUOROBENZENEBORONIC ACID 5-(dihydroxyboranyl)-2-fluorobenzoic acid |
| CAS | 120153-08-4 |
| InChI | InChI=1/C7H6BFO4/c9-6-3-4(8(12)13)1-2-5(6)7(10)11/h1-3,12-13H,(H,10,11) |
4-Fluoro-3-carboxyphenylboronic acid - Physico-chemical Properties
| Molecular Formula | C7H6BFO4 |
| Molar Mass | 183.93 |
| Density | 1.49±0.1 g/cm3(Predicted) |
| Melting Point | 236-240°C |
| Boling Point | 399.5±52.0 °C(Predicted) |
| Flash Point | 195.4°C |
| Water Solubility | Soluble in water. |
| Vapor Presure | 4.23E-07mmHg at 25°C |
| Appearance | White to white-like solid |
| pKa | 3.15±0.10(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 1.559 |
| MDL | MFCD01114671 |
4-Fluoro-3-carboxyphenylboronic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
| Hazard Note | Irritant/Keep Cold |
| Hazard Class | IRRITANT, KEEP COLD |
4-Fluoro-3-carboxyphenylboronic acid - Introduction
4-carboxy-3-fluorophenylboronic acid is an organic compound with the chemical formula C7H5FO2B. It has a colorless crystalline or white crystalline solid. The following is a description of its nature, use, formulation and safety information:
Nature:
-4-Carboxy-3-fluorophenylboronic acid is a solid at room temperature, has low solubility, and is soluble in organic solvents such as ethanol and dimethylformamide.
-It has high thermal and chemical stability.
-Under acidic conditions, it can form complexes with some compounds.
Use:
-4-carboxy-3-fluorophenylboronic acid has important applications in the field of organic synthesis. It is a commonly used organoboron reagent that can participate in the formation of C- C and C- X bonds, such as the reaction of aryl boronic acid with dehydrogenated bromobenzene to generate coupling products.
-It can also be used as a precursor of organic optoelectronic materials, such as organic light-emitting diode (OLED) materials.
Preparation Method:
-4-carboxy-3-fluorophenylboronic acid can be obtained by reacting phenylboronic acid with 2,4-difluorobenzoic acid under suitable reaction conditions.
-The specific preparation method can be heating and reacting phenylboronic acid and 2,4-difluorobenzoic acid in an organic solvent under acidic conditions, and then crystallizing and purifying.
Safety Information:
-4-Carboxy-3-fluorophenylboronic acid is generally considered to be a relatively safe compound under normal use conditions.
-However, for any chemical, always pay attention to follow appropriate laboratory safety procedures, including wearing appropriate personal protective equipment and avoiding direct contact with skin and eyes.
-If inhaled, ingested, or exposed to this compound, seek medical attention immediately.
Nature:
-4-Carboxy-3-fluorophenylboronic acid is a solid at room temperature, has low solubility, and is soluble in organic solvents such as ethanol and dimethylformamide.
-It has high thermal and chemical stability.
-Under acidic conditions, it can form complexes with some compounds.
Use:
-4-carboxy-3-fluorophenylboronic acid has important applications in the field of organic synthesis. It is a commonly used organoboron reagent that can participate in the formation of C- C and C- X bonds, such as the reaction of aryl boronic acid with dehydrogenated bromobenzene to generate coupling products.
-It can also be used as a precursor of organic optoelectronic materials, such as organic light-emitting diode (OLED) materials.
Preparation Method:
-4-carboxy-3-fluorophenylboronic acid can be obtained by reacting phenylboronic acid with 2,4-difluorobenzoic acid under suitable reaction conditions.
-The specific preparation method can be heating and reacting phenylboronic acid and 2,4-difluorobenzoic acid in an organic solvent under acidic conditions, and then crystallizing and purifying.
Safety Information:
-4-Carboxy-3-fluorophenylboronic acid is generally considered to be a relatively safe compound under normal use conditions.
-However, for any chemical, always pay attention to follow appropriate laboratory safety procedures, including wearing appropriate personal protective equipment and avoiding direct contact with skin and eyes.
-If inhaled, ingested, or exposed to this compound, seek medical attention immediately.
Last Update：2024-04-10 22:29:15
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Product Name: 4-Carboxy-3-fluorophenylboronic acid Visit Supplier Webpage Request for quotationCAS: 120153-08-4
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QQ: 3008007409
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